Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.72 |
| ▸ | KDR | P35968 | 10/20 | 0.72 |
| ▸ | AURKA | O14965 | 4/20 | 0.72 |
| ▸ | BRAF | P15056 | 3/20 | 0.72 |
| ▸ | EGFR | P00533 | 3/20 | 0.72 |
| ▸ | FLT1 | P17948 | 2/20 | 0.72 |
| ▸ | FLT4 | P35916 | 2/20 | 0.72 |
| ▸ | RAF1 | P04049 | 2/20 | 0.72 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.72 |
| ▸ | LCK | P06239 | 2/20 | 0.72 |
| ▸ | FYN | P06241 | 2/20 | 0.72 |
| ▸ | RET | P07949 | 2/20 | 0.72 |
| ▸ | SRC | P12931 | 2/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.72 |
| ▸ | LTK | P29376 | 2/20 | 0.72 |
| ▸ | TTK | P33981 | 2/20 | 0.72 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.72 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.72 |
| ▸ | BTK | Q06187 | 2/20 | 0.72 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693459 | 0.93 | MET (0.82) | METKDRAURKABRAFEGFR | |
| SCHEMBL371849 | 0.93 | MET (0.82) | METKDRAURKABRAFEGFR | |
| SCHEMBL371662 | 0.93 | MET (0.82) | METKDRAURKABRAFEGFR | |
| SCHEMBL371568 | 0.91 | MET (0.78) | METKDRAURKABRAFEGFR | |
| SCHEMBL24444623 | 0.90 | MET (0.69) | METKDRAURKABRAFEGFR | |
| SCHEMBL24444601 | 0.88 | MET (0.75) | METKDRAURKABRAFEGFR | |
| SCHEMBL29693532 | 0.88 | MET (0.73) | METKDRAURKABRAFEGFR | |
| SCHEMBL24444603 | 0.86 | MET (0.72) | METKDRAURKABRAFEGFR | |
| SCHEMBL371956 | 0.86 | MET (0.71) | METKDRAURKABRAFEGFR | |
| SCHEMBL371839 | 0.85 | MET (0.70) | METKDRAURKABRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |