Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.62 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.62 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 3/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KDM4B | O94953 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10242977 | 0.84 | HDAC3 (0.61) | SMN1; SMN2DRD2DRD3TRPV1NAAA | |
| SCHEMBL1925893 | 0.81 | SMN1; SMN2 (0.77) | SMN1; SMN2DRD2DRD3NAAAHDAC1 | |
| SCHEMBL5020897 | 0.81 | HDAC3 (0.61) | SMN1; SMN2DRD2DRD3TRPV1NAAA | |
| SCHEMBL31055462 | 0.79 | SMN1; SMN2 (0.60) | MAP4K4SMN1; SMN2CDK8KDRCAMK2D | |
| SCHEMBL10242958 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2RXFP1KDM4BCAMK2DNAAA | |
| SCHEMBL1679117 | 0.78 | PRKD3 (0.71) | MAP4K4MKNK2MAP4K5CSNK1G2CLK4 | |
| SCHEMBL31055400 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2DRD2DRD3NAAAHDAC1 | |
| SCHEMBL18943848 | 0.78 | MAP4K4 (1.00) | MAP4K4MKNK2MAP4K5CSNK1G2CLK4 | |
| SCHEMBL10242934 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2HDAC1HDAC2HDAC3KMT2A | |
| SCHEMBL2971278 | 0.77 | MAP4K4 (0.50) | MAP4K4MKNK2MAP4K5CSNK1G2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097708-B2 | 10a-Azalide compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-01-17 | — | — | US | disclosed |
| US-8097708-B2 | 10a-Azalide compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-01-17 | — | — | US | disclosed |
| US-20090281292-A1 | 10a-Azalide Compound | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2009-11-12 | — | — | US | disclosed |
| US-20090281292-A1 | 10a-Azalide Compound | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281292-A1 | 10a-Azalide Compound | IL17A, AZI2, HDAC9 | MAP4K4 4273/4885MKNK2 4059/4885MAP4K5 3925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.