Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | NAAA | Q02083 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | F2R | P25116 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927120 | 0.91 | L3MBTL1 (0.67) | SMN1; SMN2NAAAHDAC1HDAC2DRD2 | |
| SCHEMBL16117373 | 0.87 | SMN1; SMN2 (1.00) | SMN1; SMN2NAAAHDAC1HDAC2TSHR | |
| SCHEMBL6360275 | 0.86 | DRD2 (0.78) | SMN1; SMN2NAAAHDAC1HDAC2DRD2 | |
| SCHEMBL1002854 | 0.85 | NAAA (0.86) | SMN1; SMN2NAAAHDAC1HDAC2DRD2 | |
| SCHEMBL10242958 | 0.85 | SMN1; SMN2 (0.67) | SMN1; SMN2NAAAHDAC1HDAC2TSHR | |
| SCHEMBL13693382 | 0.84 | SMN1; SMN2 (0.87) | SMN1; SMN2NAAAHDAC1HDAC2TSHR | |
| SCHEMBL4439622 | 0.84 | HDAC8 (0.64) | SMN1; SMN2HDAC1HDAC2HDAC8EPHX2 | |
| Bromide SCHEMBL4760760 | 0.84 | NAAA (0.83) | SMN1; SMN2NAAAHDAC1HDAC2DRD2 | |
| SCHEMBL9503009 | 0.84 | NAAA (0.83) | SMN1; SMN2NAAAHDAC1HDAC2DRD2 | |
| Hydrochloric Acid SCHEMBL15954598 | 0.84 | NAAA (0.83) | SMN1; SMN2NAAAHDAC1HDAC2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-B1 | ALPHA-HELICAL MIMETICS | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2018-02-21 | — | — | EP | disclosed |
| US-7956216-B2 | Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2011-06-07 | — | — | US | disclosed |
| US-20080153802-A1 | Alpha-helical mimetics | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153802-A1 | Alpha-helical mimetics | BID, BAX, BAD | SMN1; SMN2 860/4885NAAA 2588/4885HDAC1 1665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.