Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.58 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371869 | 0.94 | MET (0.60) | METFLT3KDRAXL | |
| SCHEMBL371763 | 0.93 | MET (0.60) | METFLT3KDRAXLEGFR | |
| SCHEMBL371555 | 0.90 | MET (0.63) | METFLT3KDRAXL | |
| SCHEMBL14379860 | 0.89 | MET (0.58) | METFLT3KDRAXL | |
| SCHEMBL372239 | 0.88 | MET (0.61) | METFLT3KDRAXL | |
| SCHEMBL20525875 | 0.88 | MET (0.61) | METFLT3KDRAXL | |
| SCHEMBL374695 | 0.88 | MET (0.60) | METFLT3KDRAXL | |
| SCHEMBL371865 | 0.88 | MET (0.61) | METFLT3KDRAXL | |
| SCHEMBL407778 | 0.87 | MET (0.62) | METFLT3KDRAXL | |
| SCHEMBL372669 | 0.87 | MET (0.62) | METFLT3KDRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2392565-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2392564-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2213661-A1 | c-Met Modulators and Methods of Use | Exelixis Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |