Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 19/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878017 | 0.93 | GPR84 (0.58) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL883745 | 0.91 | GPR84 (0.57) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL878322 | 0.91 | GPR84 (0.57) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL10243371 | 0.91 | GPR84 (0.61) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL883759 | 0.90 | GPR84 (0.62) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL883524 | 0.90 | GPR84 (0.56) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL10246157 | 0.90 | GPR84 (0.56) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL15092721 | 0.90 | GPR84 (0.56) | GPR84KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL15092914 | 0.89 | GPR84 (0.54) | GPR84 | |
| SCHEMBL878128 | 0.87 | GPR84 (0.59) | GPR84KDM4EALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037782-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | GLAXO GROUP LIMITED (GB) | 2012-03-29 | — | — | WO | disclosed |