Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026693 | 0.82 | ALDH1A1 (0.42) | PTGS1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1026082 | 0.81 | MEN1 (0.63) | ALDH1A1KMT2AMEN1POLBRAB9A | |
| SCHEMBL1025671 | 0.81 | NR1H4 (0.48) | ALDH1A1KDM4EPOLBHTTRAB9A | |
| SCHEMBL1026084 | 0.81 | MEN1 (0.63) | ALDH1A1KMT2AMEN1POLBRAB9A | |
| SCHEMBL1028225 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL2126328 | 0.79 | PTGS1 (0.68) | PTGS1KCNK9KCNK3ALDH1A1KDM4E | |
| SCHEMBL31171978 | 0.79 | PTGS1 (0.72) | PTGS1KCNK9KCNK3ALDH1A1KDM4E | |
| SCHEMBL308208 | 0.79 | PTGS1 (0.72) | PTGS1KCNK9KCNK3ALDH1A1KDM4E | |
| SCHEMBL1025733 | 0.78 | ALDH1A1 (0.59) | ALDH1A1POLBHTTRAB9A | |
| SCHEMBL1352405 | 0.78 | PTGS1 (0.68) | PTGS1KCNK9KCNK3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |