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SCHEMBL10243411

SCHEMBL10243411

Cc1ccc2c(c1)CCn1c-2cc(OCc2cc(F)c(Oc3ccc(C)nc3)c(F)c2)nc1=O

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GPR84 Q9NQS5 17/20 0.55
▸ KDM4E B2RXH2 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ HPGD P15428 1/20 0.48
▸ MAPK1 P28482 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ PDE4A P27815 2/20 0.47
▸ PLA2G7 Q13093 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15092900 0.91 GPR84 (0.51) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL883551 0.89 GPR84 (0.51) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL883812 0.83 GPR84 (0.63) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL875374 0.83 GPR84 (0.62) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL878045 0.82 GPR84 (0.51) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL883504 0.81 GPR84 (0.50) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL878551 0.81 GPR84 (0.49) GPR84PLA2G7
SCHEMBL10243311 0.80 GPR84 (0.59) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL878236 0.79 GPR84 (0.49) GPR84KDM4EALDH1A1HPGDMAPK1
SCHEMBL883765 0.79 GPR84 (0.57) GPR84PDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037782-A1 TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES GLAXO GROUP LIMITED (GB) 2012-03-29 — — WO disclosed