Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371862 | 0.95 | MET (0.61) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL4401157 | 0.94 | MET (0.61) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371753 | 0.94 | MET (0.61) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL4401149 | 0.94 | MET (0.61) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371873 | 0.93 | MET (0.60) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371560 | 0.93 | MET (0.67) | METFLT3KDR | |
| SCHEMBL371637 | 0.93 | MET (0.67) | METFLT3KDR | |
| SCHEMBL371636 | 0.93 | MET (0.67) | METFLT3KDR | |
| SCHEMBL371641 | 0.90 | MET (0.66) | METFLT3KDRAXLPDGFRA | |
| SCHEMBL371916 | 0.90 | MET (0.63) | METFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2392565-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2392564-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |