Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23277064 | 1.00 | MAPT (0.42) | MAPTGAANPSR1BRD4F2 | |
| SCHEMBL23277063 | 1.00 | MAPT (0.42) | MAPTGAANPSR1BRD4F2 | |
| SCHEMBL23276873 | 0.88 | MAPT (0.42) | MAPTGAANPSR1BRD4F2 | |
| SCHEMBL23276872 | 0.88 | MAPT (0.42) | MAPTGAANPSR1BRD4F2 | |
| SCHEMBL14720181 | 0.86 | MAPT (0.44) | MAPTGAANPSR1BRD4F2 | |
| SCHEMBL23284252 | 0.86 | MAPT (0.44) | MAPTGAANPSR1BRD4F2 | |
| SCHEMBL14720183 | 0.86 | MAPT (0.44) | MAPTGAANPSR1BRD4F2 | |
| SCHEMBL14000524 | 0.85 | HRH3 (0.33) | MAPTGAANPSR1 | |
| SCHEMBL437950 | 0.84 | PDK1 (0.41) | MAPTGAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL437951 | 0.84 | PDK1 (0.41) | MAPTGAAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |