Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18877351 | 0.93 | FAAH (0.85) | FAAHMAPTP2RX3CNR1ALDH1A1 | |
| SCHEMBL9952848 | 0.91 | FAAH (0.82) | FAAHMAPTP2RX3CNR1ALDH1A1 | |
| SCHEMBL9952543 | 0.91 | FAAH (0.82) | FAAHMAPTP2RX3CNR1ALDH1A1 | |
| SCHEMBL18877353 | 0.91 | FAAH (0.88) | FAAHMAPTP2RX3CNR1ALDH1A1 | |
| SCHEMBL2169687 | 0.91 | FAAH (0.91) | FAAHMAPTP2RX3ALDH1A1PKM | |
| SCHEMBL9959644 | 0.90 | FAAH (0.87) | FAAHMAPTALDH1A1PKMGAA | |
| SCHEMBL2168486 | 0.90 | FAAH (1.00) | FAAHMAPTP2RX3ALDH1A1PKM | |
| SCHEMBL29392296 | 0.90 | FAAH (1.00) | FAAHMAPTP2RX3ALDH1A1PKM | |
| SCHEMBL9959484 | 0.90 | FAAH (0.80) | FAAHMAPTP2RX3CNR1ALDH1A1 | |
| SCHEMBL9953124 | 0.90 | FAAH (0.80) | FAAHMAPTP2RX3CNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088431-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |