SCHEMBL102459

SCHEMBL102459

NC(=NO)c1ccccc1OC(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.42
LMNA P02545 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
GRIN2B Q13224 4/20 0.41
KCNK3 O14649 4/20 0.40
KCNK9 Q9NPC2 4/20 0.40
GRIN1 Q05586 1/20 0.40
ALDH1A1 P00352 1/20 0.39
HSD11B1 P28845 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
F2R P25116 1/20 0.36
CLK1 P49759 1/20 0.36
MGLL Q99685 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL102458 1.00 GAA (0.42) GAALMNAL3MBTL1GRIN2BKCNK3
SCHEMBL2774058 0.88 NPSR1 (0.44) GAALMNAGRIN2BKCNK3KCNK9
SCHEMBL2774056 0.88 NPSR1 (0.44) GAALMNAGRIN2BKCNK3KCNK9
SCHEMBL23761699 0.79 ANO1 (0.44) GAAL3MBTL1KCNK3KCNK9ALDH1A1
SCHEMBL9951788 0.79 KCNK3 (0.40) GAAL3MBTL1GRIN2BKCNK3KCNK9
SCHEMBL1106365 0.79 KCNK3 (0.40) GAAL3MBTL1GRIN2BKCNK3KCNK9
SCHEMBL1179288 0.79 KCNK3 (0.40) GAAL3MBTL1GRIN2BKCNK3KCNK9
SCHEMBL11831818 0.78 NPSR1 (0.40) GAALMNAL3MBTL1ALDH1A1RXFP1
SCHEMBL6893484 0.78 KCNK3 (0.42) GAAL3MBTL1GRIN2BKCNK3KCNK9
SCHEMBL3625287 0.78 KCNK3 (0.42) GAAGRIN2BKCNK3KCNK9GRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1587784-B1 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2014-10-15 EP claimed
EP-1730232-B1 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2010-10-20 EP claimed
US-7521510-B2 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC (US) 2009-04-21 US claimed
US-7514506-B2 Fast curing fluoroelastomeric compositions, adhesive fluoroelastomeric compositions and methods for bonding fluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2009-04-07 US claimed
EP-1587784-A4 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2008-10-29 EP claimed
EP-1730232-A4 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2008-05-21 EP claimed
US-20070027260-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2007-02-01 US claimed
US-20060287438-A1 Fast curing fluoroelastomeric compositions, adhesive fluoroelastomeric compositions and methods for bonding fluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2006-12-21 US claimed
EP-1730232-A2 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2006-12-13 EP claimed
EP-1587784-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2005-10-26 EP claimed
WO-2005097890-A2 FAST CURING FLUOROELASTOMERIC COMPOSITIONS, ADHESIVE FLUOROELASTOMERIC COMPOSITIONS AND METHODS FOR BONDING FLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2005-10-20 WO claimed
US-20040214956-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2004-10-28 US claimed
WO-2004069900-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2004-08-19 WO claimed
EP-3461849-B1 METHOD OF BONDING PERFLUOROELASTOMERIC MATERIALS TO A SURFACE GREENE TWEED TECH INC (US) 2025-12-10 EP disclosed
US-11390726-B2 Method of bonding perfluoroelastomeric materials to a surface GREENE, TWEED TECHNOLOGIES, INC. (US) 2022-07-19 US disclosed
US-20210198447-A1 Method of Bonding Perfluoroelastomeric Materials to a Surface GREENE, TWEED OF DELAWARE, INC. 2021-07-01 US disclosed
US-20040214956-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2004-10-28 US disclosed
WO-2004069900-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2004-08-19 WO disclosed
EP-1385836-A2 AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS Pharmacia Corporation (US) 2004-02-04 EP disclosed
WO-2002092588-A2 AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS PHARMACIA CORPORATION (US) 2002-11-21 WO disclosed