SCHEMBL10246

SCHEMBL10246

Cc1cc2cc(Br)ccc2[nH]1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.59
KEAP1 Q14145 1/20 0.59
LMNA P02545 2/20 0.56
HPGD P15428 2/20 0.56
AXL P30530 1/20 0.55
CYP19A1 P11511 1/20 0.52
AHR P35869 1/20 0.47
NR4A2 P43354 1/20 0.47
FLT3 P36888 1/20 0.45
NOS1 P29475 1/20 0.44
METAP2 P50579 1/20 0.44
CSNK2A1 P68400 1/20 0.44
MAPT P10636 5/20 0.44
KDM4E B2RXH2 2/20 0.44
ALDH1A1 P00352 1/20 0.44
HRH4 Q9H3N8 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
PABPC1 P11940 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL27667464 0.88 HPGD (0.50) CYP2A6KEAP1LMNAHPGDAXL
SCHEMBL475358 0.83 LMNA (0.52) CYP2A6KEAP1LMNAHPGDAXL
SCHEMBL30697897 0.83 LMNA (0.52) CYP2A6KEAP1LMNAHPGDAXL
Tert-Butyl Formate SCHEMBL27667087 0.82 HPGD (0.45) CYP2A6KEAP1LMNAHPGDAXL
SCHEMBL26262642 0.78 CYP19A1 (0.47) CYP2A6KEAP1LMNAHPGDCYP19A1
SCHEMBL29727931 0.77 CYP2A6 (0.63) CYP2A6KEAP1HPGDAXLFLT3
SCHEMBL21812417 0.77 CYP19A1 (0.55) CYP2A6LMNAHPGDCYP19A1AHR
SCHEMBL17422783 0.77 CYP19A1 (0.71) CYP2A6CYP19A1AHRNR4A2FLT3
SCHEMBL75581 0.77 CYP2A6 (0.63) CYP2A6KEAP1HPGDAXLFLT3
SCHEMBL13802346 0.76 BRD4 (0.59) CYP2A6LMNAHPGDCYP19A1AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 290 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108017557-B Cyanidation method for preparing nitrile compound 中国科学院兰州化学物理研究所苏州研究院 2020-11-24 CN claimed
CN-109761875-A A kind of new method constructing amido bond 盐城工学院 2019-05-17 CN claimed
US-20260146035-A1 FUSED BICYCLIC COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS DONG-A ST CO., LTD. (KR) 2026-05-28 US disclosed
US-20250302815-A1 PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS CALICO LIFE SCIENCES LLC 2025-10-02 US disclosed
EP-4605395-A2 FUSED BICYCLIC COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS Dong-A ST Co., Ltd. (KR) 2025-08-27 EP disclosed
US-20250263760-A1 MODIFIED BACTERIA FOR PRODUCTION OF NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2025-08-21 US disclosed
US-12319946-B2 Methods for producing modified bacteria for production of nitroaromatics UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2025-06-03 US disclosed
WO-2025094117-A1 SUBSTITUTED INDOLYL COMPOUNDS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEREOF GT GAIN THERAPEUTICS SA (CH) 2025-05-08 WO disclosed
WO-2025096856-A1 COVALENT CEREBLON LIGANDS C4 THERAPEUTICS, INC. (US) 2025-05-08 WO disclosed
WO-2025082069-A1 COMPOUND BINDING TO CRBN PROTEIN AND DEGRADATION AGENT OF PROTEIN 中国海洋大学 2025-04-24 WO disclosed
CN-119841843-A Compound combined with CRBN protein and degradation agent of CRBN protein 中国海洋大学 2025-04-18 CN disclosed
US-4268438-A Cationic 1,3,4-thiadiazole dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1981-05-19 US disclosed
US-4243584-A Monoazo dyestuffs containing diazo component substituted by disulfimide and trifluoromethyl groups BAYER AKTIENGESELLSCHAFT (DE) 1981-01-06 US disclosed
EP-0014402-A1 Novel 20-0-acylmaytansinoids, process for their preparation and pharmaceutical compositions containing them Takeda Chemical Industries, Ltd. (JP) 1980-08-20 EP disclosed
EP-0004466-A1 Demethyl maytansinoids and methods for producing them Takeda Chemical Industries, Ltd. (JP) 1979-10-03 EP disclosed
US-4159265-A Phenylazopyrazolo dyestuffs including disulfimide substituent BAYER AKTIENGESELLSCHAFT (DE) 1979-06-26 US disclosed
US-4083847-A Transiently water-soluble disperse mono-azo dyes containing a diamino-methylene-carbacyl group CIBA-GEIGY CORPORATION (US) 1978-04-11 US disclosed
US-4026931-A AZO DYES, FIBER-REACTIVE; INDOLE OR 5-AMINO-PYRAZOLE COUPLING COMPONENT BAYER AKTIENGESELLSCHAFT (DT) 1977-05-31 US disclosed
US-4022763-A Sulfaphenyl-azo-phenyl-azo-aminophenyl dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-05-10 US disclosed
US-3956267-A Indole-containing disazo dyestuffs having a sulfatoalkyleneoxy-substituent BAYER AKTIENGESELLSCHAFT (DT) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302815-A1 PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS PTPN1, PTPN2, PTPN18 CYP2A6 4048/4885KEAP1 1055/4885LMNA 4758/4885
US-20260146035-A1 FUSED BICYCLIC COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS AXL, ERBB2, ERBB3 CYP2A6 3283/4885KEAP1 1130/4885LMNA 2869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.