Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.63 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371665 | 0.94 | MET (0.65) | METFLT3KDRAXL | |
| SCHEMBL371883 | 0.94 | MET (0.65) | METFLT3KDRAXL | |
| SCHEMBL372134 | 0.93 | MET (0.63) | METFLT3KDRAXL | |
| SCHEMBL372113 | 0.92 | MET (0.63) | METFLT3KDR | |
| SCHEMBL371724 | 0.92 | MET (0.63) | METFLT3KDRAXL | |
| SCHEMBL371887 | 0.92 | MET (0.62) | METFLT3KDRAXL | |
| SCHEMBL374058 | 0.91 | MET (0.61) | METFLT3KDRAXL | |
| SCHEMBL12444947 | 0.91 | MET (0.52) | METFLT3KDRAXL | |
| SCHEMBL371680 | 0.91 | MET (0.67) | METFLT3KDR | |
| SCHEMBL29693566 | 0.91 | MET (0.67) | METFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2392565-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2213661-A1 | c-Met Modulators and Methods of Use | Exelixis Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |