Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173646 | 0.77 | POLB (0.40) | POLBPKMALDH1A1CSNK2A2CSNK2B | |
| SCHEMBL10195123 | 0.72 | POLB (0.41) | POLBPKMALDH1A1CSNK2A2CSNK2B | |
| SCHEMBL22328207 | 0.72 | — | — | |
| SCHEMBL5154027 | 0.67 | CYP1A2 (0.43) | POLBPKMALDH1A1CHUKKDM4E | |
| SCHEMBL24104406 | 0.66 | GAA (0.43) | POLBALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL5382994 | 0.66 | POLB (0.44) | POLBPKMALDH1A1CSNK2A2CSNK2B | |
| SCHEMBL16865834 | 0.65 | BRS3 (0.33) | BRS3 | |
| SCHEMBL12436060 | 0.62 | POLB (0.37) | POLBPKMALDH1A1CSNK2A2CSNK2B | |
| SCHEMBL14349627 | 0.62 | RAB9A (0.43) | POLBALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL5156890 | 0.62 | CYP2D6 (0.39) | POLBPKMALDH1A1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101611-B2 | Substituted pyridazines inhibitors of MEK | ARRAY BIOPHARMA INC. (US) | 2012-01-24 | — | — | US | disclosed |