Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 9/20 | 0.66 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.40 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252751 | 0.94 | ACLY (0.71) | ACLYCYP19A1MMP1MMP2MMP9 | |
| SCHEMBL183817 | 0.92 | ACLY (0.66) | ACLYCYP19A1MMP1MMP2MMP9 | |
| SCHEMBL184772 | 0.91 | ACLY (0.70) | ACLYCYP19A1MMP1MMP2MMP9 | |
| SCHEMBL184516 | 0.91 | ACLY (0.65) | ACLYMMP1MMP2MMP9MMP8 | |
| SCHEMBL184807 | 0.90 | ACLY (0.74) | ACLYMMP1MMP2MMP9MMP8 | |
| SCHEMBL15157462 | 0.90 | ACLY (0.64) | ACLYCYP19A1MMP1MMP2MMP9 | |
| SCHEMBL10248987 | 0.90 | ACLY (0.68) | ACLYMMP1MMP2MMP9MMP8 | |
| SCHEMBL253454 | 0.89 | ACLY (0.62) | ACLYCYP19A1MMP1MMP2MMP9 | |
| SCHEMBL184201 | 0.89 | ACLY (0.65) | ACLYCYP19A1MMP1MMP2MMP9 | |
| SCHEMBL184198 | 0.87 | ACLY (0.61) | ACLYMMP1MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297103-B1 | HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-01-04 | — | — | EP | disclosed |