SCHEMBL1024884

SCHEMBL1024884

CC(C)(C)[Si](C)(C)OCCCNc1ccc(NC[C@@H](O)CNC(=O)c2ccc(Cl)s2)cc1

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
F10 P00742 5/20 0.43
MAPK1 P28482 1/20 0.39
HPGD P15428 2/20 0.36
TSHR P16473 2/20 0.36
LMNA P02545 2/20 0.36
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HSD17B10 Q99714 1/20 0.36
AR P10275 1/20 0.35
PTGS2 P35354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1024886 1.00 F10 (0.43) F10MAPK1HPGDTSHRLMNA
SCHEMBL1024324 0.95 MAPK1 (0.40) F10MAPK1HPGDTSHRLMNA
SCHEMBL3479847 0.95 MAPK1 (0.40) F10MAPK1HPGDTSHRLMNA
SCHEMBL15731743 0.79 F10 (0.48) F10MAPK1HPGDTSHRLMNA
SCHEMBL1023879 0.78 F10 (0.75) F10
SCHEMBL4458638 0.76 MAPK1 (0.44) F10MAPK1HPGDTSHRLMNA
SCHEMBL78671 0.76 HPGD (0.49) F10MAPK1HPGDTSHRLMNA
SCHEMBL4557626 0.75 MAPK1 (0.44) F10MAPK1HPGDTSHRLMNA
SCHEMBL78765 0.75 MAPK1 (0.43) F10MAPK1HPGDTSHRKDM4E
SCHEMBL3151178 0.75 MAPK1 (0.42) F10MAPK1HPGDTSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945634-B1 PHENYLENEBISOXAZOLIDINE DERIVATIVES AND THEIR USE AS ANTICOAGULANTS BAYER SCHERING PHARMA AG (DE) 2011-01-19 EP disclosed
US-20100041646-A1 Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants BAYER HEALTHCARE AG (DE) 2010-02-18 US disclosed
US-20100041646-A1 Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants BAYER HEALTHCARE AG (DE) 2010-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041646-A1 Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants SELP, SERPINC1, F2 F10 346/4885MAPK1 1561/4885HPGD 650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.