SERPINC1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6023958	0.58	4/20
SCHEMBL10157440	0.56	4/20
SCHEMBL14665995	0.56	4/20
SCHEMBL14960713	0.56	4/20
SCHEMBL15199336	0.56	4/20
SCHEMBL18883211	0.56	4/20
SCHEMBL13130300	0.55	4/20
SCHEMBL14666015	0.53	4/20
SCHEMBL29308178	0.52	4/20
SCHEMBL16509456	0.52	4/20
SCHEMBL16502382	0.51	4/20
SCHEMBL13430581	0.51	4/20
SCHEMBL14960712	0.46	4/20
SCHEMBL15984561	0.45	4/20
SCHEMBL14167122	0.45	4/20
SCHEMBL15984564	0.44	4/20
SCHEMBL29308176	0.43	4/20
SCHEMBL15984559	0.43	4/20
SCHEMBL16204006	0.42	4/20
SCHEMBL16206285	0.42	4/20

Clinical trials — most relevant to SERPINC1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography	PHASE4	UNKNOWN
Metformin Use in Cardiac Fibrosis in PAI-1 Deficiency	PHASE4	ACTIVE_NOT_RECRUITING
Atorvastatin in Acute Stroke Treatment	PHASE4	COMPLETED
A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE	PHASE4	COMPLETED
The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency	PHASE3	COMPLETED
Phase III, Efficacy and Safety of Kamada-AAT for Inhalation	PHASE3	RECRUITING
Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults	PHASE3	COMPLETED
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery	PHASE1/PHASE2	UNKNOWN
The Safety and Tolerability of SerpinPC in Healthy Men and in Men with Severe Blood Disorders (haemophilia a and B)	PHASE1/PHASE2	COMPLETED
Nebulised Rt-PA for ARDS Due to COVID-19	PHASE2	COMPLETED
A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Preventing de Novo Portal Vein Thrombosis With Antithrombin-III in Patients With Cirrhosis	PHASE1	WITHDRAWN
Belgian Antithrombin Deficiency Registry	nan	NOT_YET_RECRUITING
Identification of Predictors for the Evolution of COVID-19 Related Pneumonia by Transcriptomic and Seroproteomic	nan	UNKNOWN
Detecting Abnormal Blood Clotting in Patients With Metastatic Cancer Undergoing Surgery	nan	COMPLETED
Are Uterine Fibroids Pro-thrombotic?	nan	ACTIVE_NOT_RECRUITING
The Clinical Utility of Thrombelastography in Guiding Prophylaxis of Venous Thromboembolism Following Trauma	nan	COMPLETED
Identification and Characterization of Genetic Variants in Hereditary Angioedema	nan	NOT_YET_RECRUITING
Prospective Investigation of Antithrombin III Deficiency in Adult Patients With ECMO	nan	COMPLETED
The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation	nan	UNKNOWN
Efficacy of a Natural Components Mixture in the Treatment of Non Alcoholic Fatty Liver Disease (NAFLD)	nan	COMPLETED
Haemostatic Imbalance in Patients With Chronic Liver Disease	nan	UNKNOWN
Peripheral Vascular Disease and Nerve Stimulation	nan	COMPLETED
Inflammation Markers Over Time in Cardiovascular Disease	nan	COMPLETED
Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals	nan	COMPLETED
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO)	nan	UNKNOWN
The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study	nan	RECRUITING
Antithrombin as a Predictor of Heparin Resistance in Cardiac Surgery With Cardiopulmonary Bypass	nan	NOT_YET_RECRUITING
Genetic Architecture of Plasma T-PA and PAI-1	nan	COMPLETED
A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SERPINC1 binder may also engage these)

Protein	Name	Similarity
Q5R5A3	—	1.000	Q5R5A3 →
P41361	—	1.000	P41361 →
P32262	—	1.000	P32262 →
P32261	—	1.000	P32261 →
Q94823	—	0.994	Q94823 →
P13731	—	0.991	P13731 →
Q27086	—	0.991	Q27086 →
Q27085	—	0.990	Q27085 →
Q9V3N1	—	0.986	Q9V3N1 →
P12388	—	0.986	P12388 →
Q00387	—	0.986	Q00387 →
P68566	—	0.985	P68566 →
P22777	—	0.985	P22777 →
P68565	—	0.985	P68565 →
Q06B75	—	0.985	Q06B75 →
Q2KJH6	—	0.985	Q2KJH6 →
Q9D695	—	0.985	Q9D695 →
P19324	—	0.985	P19324 →
Q9VFC2	—	0.984	Q9VFC2 →
P33831	—	0.984	P33831 →
A0A0K8RJV9	—	0.983	A0A0K8RJV9 →
P13909	—	0.982	P13909 →
SERPINH1	Serpin H1	0.982	landscape →
Q0E8C8	—	0.982	Q0E8C8 →
P46202	—	0.982	P46202 →
P29457	—	0.982	P29457 →
Q9CQV3	—	0.981	Q9CQV3 →
P79335	—	0.981	P79335 →
Q5RBS3	—	0.981	Q5RBS3 →
Q9D7P9	—	0.981	Q9D7P9 →