Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184590 | 0.82 | ACLY (0.59) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL183990 | 0.79 | BCL2 (0.48) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL184862 | 0.79 | ACLY (0.52) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL185069 | 0.79 | ACLY (0.60) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL184826 | 0.76 | ACLY (0.61) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL2734939 | 0.75 | ACLY (0.49) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL254105 | 0.75 | ACLY (0.62) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL184743 | 0.74 | BCL2 (0.64) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL184004 | 0.74 | ACLY (0.47) | ACLYBCL2MMP1MMP2MMP9 | |
| SCHEMBL184298 | 0.73 | ACLY (0.74) | ACLYBCL2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297103-B1 | HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-01-04 | — | — | EP | disclosed |