Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | JAK3 | P52333 | 8/20 | 0.38 |
| ▸ | JAK1 | P23458 | 6/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980921 | 0.82 | CDK2 (0.43) | CDK2KCNH2CDK1TGFBR1JAK2 | |
| SCHEMBL7976853 | 0.81 | CDK2 (0.42) | CDK2KCNH2CDK1 | |
| SCHEMBL10251874 | 0.81 | CAMK2D (0.50) | CDK2KCNH2JAK2JAK3JAK1 | |
| SCHEMBL7964761 | 0.81 | HDAC1 (0.48) | CDK2KCNH2CDK1JAK2JAK3 | |
| SCHEMBL7974320 | 0.81 | IGF1R (0.42) | CDK2KCNH2CDK1TGFBR1HDAC1 | |
| SCHEMBL7995054 | 0.79 | CDK2 (0.43) | CDK2KCNH2CDK1JAK2JAK3 | |
| SCHEMBL10251999 | 0.79 | ABL1 (0.48) | CDK2KCNH2ROCK1CAMK2D | |
| SCHEMBL10252292 | 0.79 | CAMK2D (0.51) | CDK2KCNH2MAPK8CDK9MAPK10 | |
| SCHEMBL7976431 | 0.78 | CDK2 (0.42) | CDK2KCNH2CDK1JAK2JAK3 | |
| SCHEMBL10285618 | 0.77 | CDK2 (0.41) | CDK2KCNH2CDK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC7 | CDK2 16/4885KCNH2 3897/4885CDK1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.