Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 8/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413719 | 0.86 | TNIK (0.47) | TNIKPIK3CAAAK1CAMKK2CYP2C9 | |
| SCHEMBL857599 | 0.84 | BRAF (0.54) | TNIKPIK3CAAAK1CAMKK2CYP2C9 | |
| SCHEMBL878738 | 0.84 | TNIK (0.55) | TNIKPIK3CAAAK1CYP2C9CYP2C19 | |
| SCHEMBL3706659 | 0.83 | INSR (0.55) | TNIKPIK3CAAAK1CAMKK2CYP2C9 | |
| SCHEMBL298800 | 0.83 | TNIK (0.54) | TNIKPIK3CAAAK1CAMKK2CYP2C9 | |
| SCHEMBL878650 | 0.83 | TNIK (0.54) | TNIKPIK3CAAAK1SMN1; SMN2CAMKK2 | |
| SCHEMBL414867 | 0.82 | TNIK (0.53) | TNIKPIK3CAAAK1CYP2C9CYP2C19 | |
| SCHEMBL415724 | 0.82 | TNIK (0.51) | TNIKMAP2K4PIK3CARAB9ASMN1; SMN2 | |
| SCHEMBL859071 | 0.82 | TNIK (0.49) | TNIKPIK3CAAAK1SMN1; SMN2CAMKK2 | |
| SCHEMBL10256566 | 0.81 | BRD4 (0.52) | PIK3CAAAK1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053177-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2012-03-01 | — | — | US | disclosed |
| US-20120053177-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053177-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | TNIK 313/4885MAP2K4 224/4885PIK3CA 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.