INSR

Insulin receptor · P06213 · INSR on Sugi Atlas →

135,794 patent compounds predicted against INSR, 101,664 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Perchlorate (SCHEMBL74803)	0.78	16/20
Perchlorate (SCHEMBL74804)	0.78	16/20
Hydrochloric Acid (SCHEMBL40198)	0.61	15/20
SCHEMBL62618	0.52	15/20
Hydrochloric Acid (SCHEMBL39637)	0.53	10/20
Hydrochloric Acid (SCHEMBL25298)	0.59	9/20
SCHEMBL95142	1.00	8/20
SCHEMBL94862	1.00	7/20
SCHEMBL94964	0.79	7/20
Hydrochloric Acid (SCHEMBL39418)	0.59	7/20
Hydrochloric Acid (SCHEMBL39299)	0.39	7/20
Basic Blue 41 (SCHEMBL94760)	0.60	5/20
Basic Blue 41 (SCHEMBL110712)	0.60	5/20
SCHEMBL61593	0.49	5/20
SCHEMBL72316	0.48	5/20
SCHEMBL71319	0.46	5/20
Hydrochloric Acid (SCHEMBL39077)	0.46	4/20
SCHEMBL138668	0.69	3/20
SCHEMBL97762	0.64	3/20
SCHEMBL141514	0.64	3/20

Clinical trials — most relevant to INSR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway	PHASE4	COMPLETED
Effects of Losartan on Insulin Resistance in Patients With Heart Failure	PHASE4	COMPLETED
Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer	PHASE4	WITHDRAWN
A Dose-response Study Examining the Contribution of GLP-1 Receptor Signaling to Glucagon-stimulated Insulin Secretion	PHASE3	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Cinnamomum Cassia Effect on IGF1 and Metabolic Control in Patients With DM2 Without Glycemic Control Metformin Treated	PHASE3	COMPLETED
Effect of the Chromium Nicotinate on Type 2 Diabetes	PHASE3	UNKNOWN
Effects of Liraglutide in Young Adults With Type 2 DIAbetes (LYDIA)	PHASE3	COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus	PHASE3	COMPLETED
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes	PHASE2	RECRUITING
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes	PHASE2	RECRUITING
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors	PHASE1	WITHDRAWN
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans	PHASE1	COMPLETED
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans	nan	UNKNOWN
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients	nan	UNKNOWN
Hepatic Metabolic Changes in Response to Glucagon Infusion	nan	COMPLETED
AR, IGF-IR, IR and Peripheral Artery Disease	nan	UNKNOWN
Brain Insulin Resistance in Mild Cognitive Impairment	nan	UNKNOWN
Is There Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?	nan	UNKNOWN
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes	nan	RECRUITING
IRS Proteins and Trastuzumab Resistance	nan	COMPLETED
Diagnostic Value of MicroRNA 210 In Preeclampsia	nan	UNKNOWN
Insulin Sensitivity and Testosterone Response to Aerobic Exercise Versus Added Sugar Elimination in Polycystic Ovary Syndrome Women	nan	NOT_YET_RECRUITING
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.	nan	COMPLETED
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle	nan	UNKNOWN
Incidence and Course of Stress Hyperglycemia in Critically Ill Children Admitted to PICU of Assiut University Children Hospital	nan	UNKNOWN
The Effects of Citric and Malic Acid Found in Pomegranate Juice on Glycaemic Response to White Bread.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a INSR binder may also engage these)

Protein	Name	Similarity
P15208	—	1.000	P15208 →
P15127	—	1.000	P15127 →
O73798	—	1.000	O73798 →
Q60751	—	0.997	Q60751 →
Q9PVZ4	—	0.997	Q9PVZ4 →
Q93105	—	0.997	Q93105 →
P24062	—	0.996	P24062 →
IGF1R	Insulin-like growth factor 1 receptor	0.994	landscape →
P14617	—	0.994	P14617 →
PTPRM	Receptor-type tyrosine-protein phosphatase mu	0.993	landscape →
INSRR	Insulin receptor-related protein	0.992	landscape →
P35546	—	0.991	P35546 →
Q9WTL4	—	0.991	Q9WTL4 →
O02466	—	0.991	O02466 →
EPHA6	Ephrin type-A receptor 6	0.991	landscape →
A1X150	—	0.991	A1X150 →
Q60629	—	0.991	Q60629 →
Q00PJ8	—	0.991	Q00PJ8 →
Q92729	—	0.990	Q92729 →
P54757	—	0.990	P54757 →
Q07E01	—	0.990	Q07E01 →
Q2QLA9	—	0.990	Q2QLA9 →
Q75ZY9	—	0.990	Q75ZY9 →
Q99M80	—	0.990	Q99M80 →
Q09YK0	—	0.990	Q09YK0 →
A0M8R7	—	0.989	A0M8R7 →
Q07DZ1	—	0.989	Q07DZ1 →
Q64716	—	0.989	Q64716 →
P26619	—	0.989	P26619 →
Q769I5	—	0.989	Q769I5 →