Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680992 | 0.87 | AKT1 (0.43) | FFAR2SMN1; SMN2L3MBTL1POLBRAB9A | |
| SCHEMBL8227309 | 0.85 | FFAR2 (0.44) | FFAR2SMN1; SMN2L3MBTL1POLBBRD4 | |
| SCHEMBL14310526 | 0.85 | BRD4 (0.49) | FFAR2SMN1; SMN2L3MBTL1KDM4EPOLB | |
| SCHEMBL679637 | 0.85 | AKT1 (0.45) | FFAR2SMN1; SMN2L3MBTL1KDM4EPOLB | |
| SCHEMBL681207 | 0.82 | FFAR2 (0.42) | FFAR2SMN1; SMN2L3MBTL1POLBALDH1A1 | |
| SCHEMBL12104141 | 0.82 | KDM4E (0.40) | FFAR2SMN1; SMN2L3MBTL1KDM4EPOLB | |
| SCHEMBL680742 | 0.81 | FFAR2 (0.41) | FFAR2SMN1; SMN2L3MBTL1POLBRAB9A | |
| SCHEMBL680697 | 0.81 | FFAR2 (0.41) | FFAR2SMN1; SMN2L3MBTL1POLBRAB9A | |
| SCHEMBL681425 | 0.81 | FFAR2 (0.44) | FFAR2L3MBTL1POLBALDH1A1RAB9A | |
| SCHEMBL680933 | 0.81 | KDM4E (0.40) | FFAR2L3MBTL1KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |