FFAR2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1677068	0.62	18/20
SCHEMBL1677071	0.62	18/20
SCHEMBL1677147	0.62	18/20
SCHEMBL68169	0.65	17/20
SCHEMBL1405698	0.65	17/20
SCHEMBL1677207	0.65	17/20
SCHEMBL324732	0.59	17/20
SCHEMBL799703	0.49	12/20
SCHEMBL683207	0.44	11/20
SCHEMBL1564845	0.63	9/20
SCHEMBL1565494	0.61	9/20
SCHEMBL1565145	0.60	9/20
SCHEMBL1565596	0.60	9/20
SCHEMBL1565505	0.56	9/20
SCHEMBL1565300	0.53	9/20
SCHEMBL683644	0.42	9/20
SCHEMBL387916	0.40	9/20
SCHEMBL1565607	0.57	8/20
SCHEMBL1565296	0.55	8/20
SCHEMBL1565430	0.54	8/20

Clinical trials — most relevant to FFAR2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Fat, Inflammation and Insulin Resistance	PHASE4	COMPLETED
Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH)	PHASE4	COMPLETED
Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity	PHASE4	COMPLETED
Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes	PHASE4	COMPLETED
The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion	PHASE4	COMPLETED
The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome	PHASE2/PHASE3	COMPLETED
Trimetazidine as an Adjunct to Enhance Clopidogrel Response.	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Molecular Pathways Related to Short-term Fasting Response	nan	COMPLETED
The Effects of TZD on Fat Metabolism and Insulin Sensitivity in GH-Replaced GHD Patients	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
FFA Hypertension and Inflammation in Lean and Obese Subjects	nan	COMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Meal-regulated Substrate Metabolism, Influence of Obesity and IL-6	nan	COMPLETED
Effects of Fats on Blood Glucose in People With and Without Type 2 Diabetes Mellitus	nan	COMPLETED
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity	nan	COMPLETED
Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women	nan	COMPLETED
The Influence of Breakfast on Hormone Responses and Cognitive Performance	nan	COMPLETED
Fat-induced Release of GLP-1 in Humans	nan	COMPLETED
Study of Changes in Skeletal Muscle After Caloric Restriction	nan	ACTIVE_NOT_RECRUITING
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis	nan	COMPLETED
Impact of Plasma Lipids on β Cell Function and Insulin Sensitivity	nan	COMPLETED
Fetuin-A as a Marker in Obesity and Type 2 Diabetes Mellitus	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FFAR2 binder may also engage these)

Protein	Name	Similarity
Q8VCK6	—	0.998	Q8VCK6 →
Q76EI6	—	0.997	Q76EI6 →
B2GV46	—	0.994	B2GV46 →
Q3UFD7	—	0.993	Q3UFD7 →
O15529	—	0.991	O15529 →
FFAR3	Free fatty acid receptor 3	0.991	landscape →
Q86VZ1	—	0.981	Q86VZ1 →
Q8BUD0	—	0.979	Q8BUD0 →
Q8C131	—	0.979	Q8C131 →
Q9ES90	—	0.978	Q9ES90 →
O46685	—	0.978	O46685 →
GPR55	G-protein coupled receptor 55	0.976	landscape →
GPR4	G-prodeshotein coupled receptor 4	0.976	landscape →
GPR68	G-protein coupled receptor 68	0.974	landscape →
Q9Z282	—	0.974	Q9Z282 →
GPR132	Probable G-protein coupled receptor 132	0.974	landscape →
Q4KLH9	—	0.974	Q4KLH9 →
Q8BFQ3	—	0.973	Q8BFQ3 →
Q1JQB3	—	0.973	Q1JQB3 →
P50132	—	0.972	P50132 →
GPR35	G-protein coupled receptor 35	0.972	landscape →
P30558	—	0.972	P30558 →
Q09QM4	—	0.971	Q09QM4 →
Q6NS65	—	0.970	Q6NS65 →
HCAR1	Hydroxycarboxylic acid receptor 1	0.970	landscape →
P55086	—	0.969	P55086 →
Q8BLG2	—	0.969	Q8BLG2 →
A7YY44	—	0.968	A7YY44 →
O88855	—	0.968	O88855 →
Q8BYC4	—	0.968	Q8BYC4 →