Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL568645 | 0.85 | BACE2 (0.56) | BACE2 | |
| SCHEMBL568646 | 0.85 | BACE2 (0.56) | BACE2 | |
| SCHEMBL10261209 | 0.77 | BACE2 (0.53) | BACE2BACE1 | |
| SCHEMBL10259304 | 0.77 | BACE2 (0.42) | BACE2BACE1 | |
| SCHEMBL10259271 | 0.77 | BACE1 (0.43) | BACE2BACE1 | |
| SCHEMBL10261554 | 0.77 | BACE2 (0.63) | BACE2BACE1 | |
| SCHEMBL13836090 | 0.73 | BACE1 (0.55) | BACE2BACE1 | |
| SCHEMBL13836091 | 0.73 | BACE1 (0.55) | BACE2BACE1 | |
| SCHEMBL13836088 | 0.73 | BACE1 (0.55) | BACE2BACE1 | |
| SCHEMBL10267525 | 0.73 | ROCK2 (0.43) | BACE2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035195-A1 | 1,4,5,6-TETRAHYDRO-PYRIMIDIN-2-YLAMINE COMPOUNDS | SIENA BIOTECH S.P.A., AN ITALIAN COMPANY (IT) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035195-A1 | 1,4,5,6-TETRAHYDRO-PYRIMIDIN-2-YLAMINE COMPOUNDS | BACE2, BACE1, PSEN2 | BACE2 1/4885BACE1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.