Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.58 |
| ▸ | GPR142 | Q7Z601 | 7/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.49 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.49 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.49 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.49 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.49 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.49 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.49 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27744390 | 1.00 | ROCK2 (0.58) | ROCK2ROCK1GPR142AAK1PSMB8 | |
| SCHEMBL4522441 | 1.00 | ROCK2 (0.58) | ROCK2ROCK1GPR142AAK1PSMB8 | |
| SCHEMBL10260922 | 0.85 | SMN1; SMN2 (0.65) | ROCK2ROCK1GPR142AAK1PSMB8 | |
| SCHEMBL16254380 | 0.85 | CYP2D6 (0.54) | GPR142MAPK1SMN1; SMN2 | |
| SCHEMBL13478043 | 0.84 | MEN1 (0.54) | GPR142MAPK1SMN1; SMN2 | |
| SCHEMBL4523811 | 0.83 | ROCK2 (0.62) | ROCK2ROCK1GPR142AAK1RPS6KA5 | |
| SCHEMBL4526393 | 0.83 | ROCK2 (0.62) | ROCK2ROCK1GPR142AAK1RPS6KA5 | |
| SCHEMBL27723735 | 0.83 | ROCK2 (0.62) | ROCK2ROCK1GPR142AAK1RPS6KA5 | |
| SCHEMBL10260920 | 0.82 | ROCK2 (0.58) | ROCK2ROCK1AAK1TAAR1RPS6KA5 | |
| SCHEMBL10259979 | 0.82 | ROCK2 (0.58) | ROCK2ROCK1AAK1TAAR1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| CN-101253152-A | Amide derivatives as ROCK inhibitors | ASTELLAS PHARMA INC (JP) | 2008-08-27 | — | — | CN | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885GPR142 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.