Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.70 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10260711 | 1.00 | HRH3 (0.70) | HRH3TLR7HTR3AKCNH2 | |
| SCHEMBL10260710 | 0.83 | HRH3 (0.65) | HRH3HTR3AKCNH2 | |
| SCHEMBL1373040 | 0.82 | HRH3 (1.00) | HRH3TLR7HTR3A | |
| SCHEMBL1373037 | 0.82 | HRH3 (1.00) | HRH3TLR7HTR3A | |
| SCHEMBL1374936 | 0.82 | HRH3 (1.00) | HRH3TLR7HTR3A | |
| SCHEMBL10259760 | 0.82 | HRH3 (0.66) | HRH3HTR3AKCNH2 | |
| SCHEMBL10259496 | 0.82 | HRH3 (0.52) | HRH3HTR3A | |
| SCHEMBL10267637 | 0.82 | HRH3 (0.52) | HRH3HTR3A | |
| SCHEMBL13141136 | 0.78 | HRH3 (0.53) | HRH3KCNH2 | |
| SCHEMBL10259312 | 0.78 | HRH3 (0.54) | HRH3HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207168-B2 | Pyridazinone derivatives | CEPHALON, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100280007-A1 | Pyridazinone Derivatives | CEPHALON, INC. (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280007-A1 | Pyridazinone Derivatives | HRH3, HNMT, HRH4 | HRH3 1/4885TLR7 2654/4885HTR3A 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.