HNMT

Histamine N-methyltransferase · P50135 · HNMT on Sugi Atlas →

1,286 patent compounds predicted against HNMT, 1,208 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6341709	0.73	2/20
SCHEMBL14174632	0.73	2/20
SCHEMBL14174701	0.56	2/20
SCHEMBL13978098	0.55	2/20
SCHEMBL14174715	0.55	2/20
SCHEMBL9080250	0.47	2/20
SCHEMBL9663409	0.43	2/20
Adenine (SCHEMBL9663399)	0.40	2/20
SCHEMBL7278886	0.39	2/20
SCHEMBL7278897	0.39	2/20
SCHEMBL7279752	0.39	2/20
SCHEMBL7279764	0.39	2/20
SCHEMBL4247653	0.36	2/20
SCHEMBL4248836	0.34	2/20
S-Adenosylhomocysteine (SCHEMBL8836)	1.00	1/20
Amodiaquine (SCHEMBL317888)	1.00	1/20
S-Adenosylhomocysteine (SCHEMBL804238)	1.00	1/20
S-Adenosylhomocysteine (SCHEMBL5273228)	1.00	1/20
S-Adenosylhomocysteine (SCHEMBL10871157)	1.00	1/20
Amodiaquine (SCHEMBL12094969)	1.00	1/20

Clinical trials — most relevant to HNMT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Histidine Oral Supplementation as a Therapeutic Modality for Alzheimer's Disease	PHASE4	WITHDRAWN
Effects of Sex Steroids on the Serotonin System	PHASE4	UNKNOWN
Interleukin-2 With or Without Histamine Dihydrochloride in Treating Patients With Stage IV Melanoma Metastatic to the Liver	PHASE3	UNKNOWN
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study)	PHASE3	COMPLETED
Study to Investigate the Effects of Different Doses of S-adenosyl-L-methionine (SAMe) in Subjects With Nonalcoholic Fatty Liver Disease and Non-treated Matched Healthy Volunteers as Control Group	PHASE3	COMPLETED
Adjuvant Use of Neostigmine in Sepsis and Septic Shock.	PHASE2	COMPLETED
Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans	PHASE2	NOT_YET_RECRUITING
Effects of Betahistine Hydrochloride in Overweight Women	PHASE1	COMPLETED
Molecular Imaging Study of Harmine/DMT: a Basic Research Approach	PHASE1	COMPLETED
Vancomycin Associated Red Man Syndrome (RMS)	nan	COMPLETED
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Histamine Pharmacogenetics in Children With Atopic Dermatitis	nan	COMPLETED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
The Efficacy of L-cysteine in Prevention of Headache Attacks in Migraine Patients	nan	COMPLETED
Melatonin in Pregnancy	nan	COMPLETED
Human Requirements for the Nutrient Choline	nan	COMPLETED
Effects of PBMT-sMF in Mechanically Ventilated Patients	nan	RECRUITING
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients	nan	COMPLETED
Neural Response to Catecholamine Depletion in Subjects Suffering From Bulimia Nervosa in Their Past and Healthy Controls	nan	SUSPENDED
Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin Prick	nan	COMPLETED
Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism	nan	COMPLETED
Genetic Variants and Regulation of Specialized Pro-resolving Mediator	nan	RECRUITING
Choline Dose Ranging in Postmenopausal Women	nan	COMPLETED
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer	nan	COMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Antihistamines, Amantadine and Evolution of COVID-19	nan	RECRUITING
The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia	nan	COMPLETED
Exploration of Glutamatergic System With PET Radiotracer in Gilles de la Tourette Patients: Pilot Study (GlutaTour)	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a HNMT binder may also engage these)

Protein	Name	Similarity
Q5R7C3	—	1.000	Q5R7C3 →
Q91VF2	—	1.000	Q91VF2 →
Q7SYS9	—	1.000	Q7SYS9 →
Q4SBY6	—	1.000	Q4SBY6 →
Q58DV7	—	1.000	Q58DV7 →
Q9EST2	—	1.000	Q9EST2 →
Q01984	—	1.000	Q01984 →
Q6DC37	—	1.000	Q6DC37 →
Q0V9P1	—	0.998	Q0V9P1 →
U3NEE3	—	0.994	U3NEE3 →
Q8R4Z9	—	0.985	Q8R4Z9 →
Q811U4	—	0.985	Q811U4 →
A0A1D6NER6	—	0.984	A0A1D6NER6 →
F4IQJ2	—	0.983	F4IQJ2 →
Q8VYX1	—	0.983	Q8VYX1 →
P34254	—	0.982	P34254 →
SMS	Spermine synthase	0.982	landscape →
AS3MT	Arsenite methyltransferase	0.982	landscape →
P97355	—	0.982	P97355 →
Q5K651	—	0.982	Q5K651 →
Q69Z37	—	0.981	Q69Z37 →
Q9STV0	—	0.981	Q9STV0 →
Q8IVG5	—	0.981	Q8IVG5 →
Q6GM53	—	0.981	Q6GM53 →
A8E7G4	—	0.981	A8E7G4 →
Q8IWA4	—	0.981	Q8IWA4 →
A0A075D6M1	—	0.981	A0A075D6M1 →
Q63663	—	0.981	Q63663 →
Q8VHT6	—	0.981	Q8VHT6 →
Q8C3Y4	—	0.981	Q8C3Y4 →