Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14549339 | 0.86 | LMNA (0.46) | ALDH1A1MAPTLMNAUSP2NPC1L1 | |
| SCHEMBL26653397 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL29486944 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL29486942 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL26653679 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL11232551 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL11232557 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL26653400 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL26653683 | 0.82 | LMNA (0.63) | ALDH1A1MAPTALOX15LMNAUSP2 | |
| SCHEMBL13324310 | 0.74 | GPBAR1 (0.72) | MAPTLMNAUSP2CYP3A4GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119585-A1 | STEROL DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD (JP) | 2015-04-30 | — | — | US | disclosed |
| US-20150119585-A1 | STEROL DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD (JP) | 2015-04-30 | — | — | US | disclosed |
| US-8952003-B2 | Sterol derivative | KYOWA HAKKO KIRIN CO., LTD (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8952003-B2 | Sterol derivative | KYOWA HAKKO KIRIN CO., LTD (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20120172348-A1 | STEROL DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-07-05 | — | — | US | disclosed |
| US-20120172348-A1 | STEROL DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-07-05 | — | — | US | disclosed |
| US-20110020931-A1 | PROLIFERATION PROMOTING AGENT FOR NEURAL STEM CELLS | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-01-27 | — | — | US | disclosed |
| US-20110020931-A1 | PROLIFERATION PROMOTING AGENT FOR NEURAL STEM CELLS | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172348-A1 | STEROL DERIVATIVE | NR1H3, NR1H2, SREBF1 | ALDH1A1 1621/4885MAPT 3023/4885ALOX15 920/4885 |
| US-20150119585-A1 | STEROL DERIVATIVE | NR1H3, NR1H2, SREBF1 | ALDH1A1 1621/4885MAPT 3023/4885ALOX15 920/4885 |
| US-20110020931-A1 | PROLIFERATION PROMOTING AGENT FOR NEURAL STEM CELLS | NES, CALD1, BRD1 | ALDH1A1 1424/4885MAPT 1505/4885ALOX15 2482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.