Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 7/20 | 0.59 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4498126 | 0.99 | HTR1F (0.58) | HTR1FMAPK7SCDRAB9AHPGD | |
| SCHEMBL10261919 | 0.93 | HTR1F (0.54) | HTR1FMAPK7SCDRAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL4506091 | 0.92 | HTR1F (0.53) | HTR1FMAPK7SCDRAB9ANPC1 | |
| SCHEMBL4506973 | 0.92 | HTR1F (0.58) | HTR1FRAB9AHPGDNPC1WDR5 | |
| SCHEMBL10267494 | 0.86 | GRM4 (0.51) | RAB9ANPC1RORC | |
| SCHEMBL10267789 | 0.86 | HTR1F (0.57) | HTR1FHPGDWDR5 | |
| Hydrochloric Acid SCHEMBL4509011 | 0.85 | GRM4 (0.50) | RAB9ANPC1RORC | |
| Hydrochloric Acid SCHEMBL4507131 | 0.85 | HTR1F (0.56) | HTR1FHPGDWDR5 | |
| SCHEMBL10267808 | 0.84 | HTR1F (0.53) | HTR1FMAPK7SCDHTR1DSLC5A7 | |
| Hydrochloric Acid SCHEMBL4509359 | 0.84 | HTR1F (0.52) | HTR1FMAPK7SCDHTR1DSLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626958-B1 | (PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT 1F AGONISTS | LILLY CO ELI (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608629-B2 | (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 2009-10-27 | — | — | US | disclosed |