HTR1F

5-hydroxytryptamine receptor 1F · P30939 · HTR1F on Sugi Atlas →

23,491 patent compounds predicted against HTR1F, 15,364 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL1198123)	0.64	20/20
Lasmiditan (SCHEMBL536057)	1.00	19/20
Hydrochloric Acid (SCHEMBL1197687)	0.64	18/20
Hydrochloric Acid (SCHEMBL1198006)	0.69	17/20
Hydrochloric Acid (SCHEMBL1196869)	0.69	16/20
Hydrochloric Acid (SCHEMBL1197490)	0.68	16/20
Hydrochloric Acid (SCHEMBL1198211)	0.70	15/20
Hydrochloric Acid (SCHEMBL1197423)	0.66	15/20
Hydrochloric Acid (SCHEMBL1197484)	0.55	14/20
SCHEMBL1198128	0.52	14/20
SCHEMBL1198194	0.52	14/20
SCHEMBL1198119	0.64	13/20
SCHEMBL1197857	0.53	13/20
SCHEMBL1198038	0.60	12/20
SCHEMBL1197874	0.60	12/20
Hydrochloric Acid (SCHEMBL1198027)	0.55	12/20
SCHEMBL1198089	0.59	11/20
Hydrochloric Acid (SCHEMBL1197548)	0.52	11/20
Hydrochloric Acid (SCHEMBL1197652)	0.57	10/20
SCHEMBL1197035	0.53	10/20

Clinical trials — most relevant to HTR1F by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration	PHASE4	COMPLETED
Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks	PHASE3	UNKNOWN
Sumatriptan as Treatment for Post-traumatic Headache	PHASE2	COMPLETED
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder	PHASE2	RECRUITING
Evaluation of [18F]MPPF as a Brain Tracer of Serotonin Receptor 5HT1a	PHASE1	COMPLETED
Brain Imaging, Genetics and Treatment for Major Depression	PHASE1	WITHDRAWN
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF)	nan	RECRUITING
Hormonal Causes of Menstrual-Related Mood Disorders	nan	COMPLETED
PET Whole Body Distribution Studies Using [11C]CUMI	nan	COMPLETED
Acute Intermittent Hypoxia and Body Weight Supported Treadmill Training for Incomplete Spinal Cord Injury Patients	nan	COMPLETED
Trazodone and the Risk of Serious Adverse Events	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression	nan	NOT_YET_RECRUITING
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients	nan	UNKNOWN
Serotonin in Alcoholism	nan	COMPLETED
Investigating Serotonin Signalling in IBD Patients	nan	RECRUITING
Endophenotype, Molecular Genetic Study on Attention-Deficit/Hyperactivity Disorder	nan	COMPLETED
Effects of Lurasidone on Left Ventricle Systolic Functions	nan	NOT_YET_RECRUITING
Intern Health Study	nan	ENROLLING_BY_INVITATION
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HTR1F binder may also engage these)

Protein	Name	Similarity
Q9N2D9	—	1.000	Q9N2D9 →
O08890	—	1.000	O08890 →
Q02284	—	1.000	Q02284 →
P30940	—	1.000	P30940 →
P79748	—	1.000	P79748 →
HTR1E	5-hydroxytryptamine receptor 1E	1.000	landscape →
O42385	—	0.997	O42385 →
Q9N2B6	—	0.996	Q9N2B6 →
Q90WY4	—	0.995	Q90WY4 →
HTR1B	5-hydroxytryptamine receptor 1B	0.994	landscape →
Q6VB83	—	0.994	Q6VB83 →
P79250	—	0.994	P79250 →
Q9N2B7	—	0.993	Q9N2B7 →
Q98998	—	0.992	Q98998 →
P42288	—	0.992	P42288 →
Q62758	—	0.992	Q62758 →
Q95136	—	0.991	Q95136 →
P42289	—	0.991	P42289 →
O42384	—	0.991	O42384 →
Q6XXX8	—	0.991	Q6XXX8 →
O77680	—	0.990	O77680 →
O73810	—	0.989	O73810 →
Q6TLI9	—	0.989	Q6TLI9 →
P60026	—	0.989	P60026 →
P11614	—	0.988	P11614 →
P52702	—	0.988	P52702 →
HTR5A	5-hydroxytryptamine receptor 5A	0.988	landscape →
HTR4	5-hydroxytryptamine receptor 4	0.988	landscape →
Q588Y6	—	0.988	Q588Y6 →
Q9N298	—	0.988	Q9N298 →