Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | APAF1 | O14727 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CCR2 | P41597 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | ARHGDIA | P52565 | 2/20 | 0.55 |
| ▸ | ULK1 | O75385 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1716264 | 1.00 | ROCK2 (0.67) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL14514386 | 1.00 | ROCK2 (0.67) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL10262620 | 0.94 | KDM4E (0.71) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL5642369 | 0.94 | KDM4E (0.71) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL14514396 | 0.94 | KDM4E (0.71) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL1716377 | 0.94 | KDM4E (0.71) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL14514394 | 0.94 | KDM4E (0.71) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL14514393 | 0.94 | KDM4E (0.71) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL1717403 | 0.90 | ROCK2 (0.77) | ROCK2ROCK1KDM4EMEN1APAF1 | |
| SCHEMBL5413532 | 0.89 | KDM4E (0.76) | ROCK2ROCK1KDM4EMEN1APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1256574-B1 | NITROGEN-CONTAINING COMPOUNDS HAVING KINASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | KYOWA HAKKO KIRIN CO LTD (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |