Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14926166 | 0.80 | PDE10A (0.37) | SMN1; SMN2PDE10ALMNACDK8ACVR1 | |
| SCHEMBL16081467 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRLMNAADORA2BMEN1 | |
| SCHEMBL20916994 | 0.77 | TSHR (0.36) | SMN1; SMN2TSHRLMNAMEN1KMT2A | |
| SCHEMBL16092001 | 0.77 | PDE10A (0.35) | PDE10A | |
| SCHEMBL10263499 | 0.74 | SMN1; SMN2 (0.39) | SMN1; SMN2TSHRLMNAADORA2BMEN1 | |
| SCHEMBL27962400 | 0.74 | MEN1 (0.39) | SMN1; SMN2TSHRLMNAMEN1KMT2A | |
| SCHEMBL12650339 | 0.74 | CDK8 (0.40) | SMN1; SMN2LMNAADORA2BMEN1KMT2A | |
| SCHEMBL24464235 | 0.72 | LMNA (0.40) | SMN1; SMN2LMNAADORA2BMEN1KMT2A | |
| SCHEMBL10202026 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRLMNAADORA2BMEN1 | |
| SCHEMBL20917714 | 0.72 | KDM4E (0.41) | LMNAADORA2BGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368641-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORP (US) | 2025-12-04 | — | — | US | disclosed |
| US-12378243-B2 | Quinoline compounds as inhibitors of KRAS | INCYTE CORPORATION (US) | 2025-08-05 | — | — | US | disclosed |
| US-20240368152-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION | 2024-11-07 | — | — | US | disclosed |
| EP-4415824-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-08-21 | — | — | EP | disclosed |
| CN-118525017-A | Quinoline compounds as KRAS inhibitors | 因赛特公司 | 2024-08-20 | — | — | CN | disclosed |
| US-11939328-B2 | Quinoline compounds as inhibitors of KRAS | INCYTE CORPORATION (US) | 2024-03-26 | — | — | US | disclosed |
| CN-111406045-B | Process for producing herbicidal pyridazinone compounds | 先正达参股股份有限公司 | 2023-08-29 | — | — | CN | disclosed |
| US-20230144051-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION | 2023-05-11 | — | — | US | disclosed |
| US-20230144051-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION | 2023-05-11 | — | — | US | disclosed |
| US-20230144051-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION | 2023-05-11 | — | — | US | disclosed |
| EP-3697760-B1 | PROCESS FOR PRODUCING HERBICIDAL PYRIDAZINONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2023-03-08 | — | — | EP | disclosed |
| US-11254643-B2 | Process for producing herbicidal pyridazinone compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2022-02-22 | — | — | US | disclosed |
| US-11254643-B2 | Process for producing herbicidal pyridazinone compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2022-02-22 | — | — | US | disclosed |
| US-20210024470-A1 | PROCESS FOR PRODUCING HERBICIDAL PYRIDAZINONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2021-01-28 | — | — | US | disclosed |
| US-20210024470-A1 | PROCESS FOR PRODUCING HERBICIDAL PYRIDAZINONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2021-01-28 | — | — | US | disclosed |
| EP-3697760-A1 | PROCESS FOR PRODUCING HERBICIDAL PYRIDAZINONE COMPOUNDS | Syngenta Participations AG (CH) | 2020-08-26 | — | — | EP | disclosed |
| CN-111406045-A | Method for producing herbicidal pyridazinone compound | 先正达参股股份有限公司 | 2020-07-10 | — | — | CN | disclosed |
| WO-2019076930-A1 | PROCESS FOR PRODUCING HERBICIDAL PYRIDAZINONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-04-25 | — | — | WO | disclosed |
| WO-2019076930-A1 | PROCESS FOR PRODUCING HERBICIDAL PYRIDAZINONE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2019-04-25 | — | — | WO | disclosed |
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BERTHEL STEVEN JOSEPH (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024470-A1 | PROCESS FOR PRODUCING HERBICIDAL PYRIDAZINONE COMPOUNDS | CYP1B1, CYP1A1, CYP4B1 | SMN1; SMN2 4123/4885TSHR 1054/4885PDE10A 1949/4885 |
| US-12378243-B2 | Quinoline compounds as inhibitors of KRAS | KRAS, NRAS, HRAS | SMN1; SMN2 3339/4885TSHR 4707/4885PDE10A 3604/4885 |
| US-20240368152-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | KRAS, NRAS, HRAS | SMN1; SMN2 3339/4885TSHR 4707/4885PDE10A 3604/4885 |
| US-20230144051-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | KRAS, NRAS, HRAS | SMN1; SMN2 3339/4885TSHR 4707/4885PDE10A 3604/4885 |
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | SMN1; SMN2 4068/4885TSHR 2146/4885PDE10A 867/4885 |
| US-20250368641-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | KRAS, NRAS, HRAS | SMN1; SMN2 3339/4885TSHR 4707/4885PDE10A 3604/4885 |
| US-11939328-B2 | Quinoline compounds as inhibitors of KRAS | KRAS, NRAS, HRAS | SMN1; SMN2 3339/4885TSHR 4707/4885PDE10A 3604/4885 |
| US-11254643-B2 | Process for producing herbicidal pyridazinone compounds | CYP1B1, CYP1A1, CYP4B1 | SMN1; SMN2 4123/4885TSHR 1054/4885PDE10A 1949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.