Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.63 |
| ▸ | RAF1 | P04049 | 9/20 | 0.63 |
| ▸ | KDR | P35968 | 10/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546516 | 0.89 | BRAF (0.62) | BRAFRAF1KDR | |
| SCHEMBL546114 | 0.87 | BRAF (0.76) | BRAFRAF1KDR | |
| SCHEMBL545232 | 0.87 | BRAF (0.66) | BRAFRAF1KDR | |
| SCHEMBL10267992 | 0.85 | BRAF (0.46) | BRAFRAF1KDRMAPK14 | |
| SCHEMBL545703 | 0.83 | BRAF (0.68) | BRAFRAF1KDR | |
| SCHEMBL546182 | 0.83 | BRAF (0.77) | BRAFRAF1KDR | |
| SCHEMBL5428348 | 0.82 | BRAF (0.77) | BRAFRAF1KDR | |
| SCHEMBL546566 | 0.82 | BRAF (0.64) | BRAFRAF1KDR | |
| SCHEMBL545994 | 0.82 | BRAF (0.68) | BRAFRAF1KDR | |
| SCHEMBL545906 | 0.82 | BRAF (0.68) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |