Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.46 |
| ▸ | RAF1 | P04049 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 9/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545894 | 0.88 | BRAF (0.58) | BRAFRAF1KDRMAPK14 | |
| SCHEMBL10263595 | 0.85 | BRAF (0.63) | BRAFRAF1KDRMAPK14 | |
| SCHEMBL545430 | 0.80 | BRAF (0.54) | BRAFRAF1KDRMAPK14 | |
| SCHEMBL545934 | 0.75 | RAF1 (0.75) | BRAFRAF1KDRMAPK14 | |
| SCHEMBL10263025 | 0.75 | MEN1 (0.44) | BRAFKDRMAPK14 | |
| SCHEMBL10262734 | 0.74 | P2RX3 (0.44) | BRAFRAF1KDRMAPK14P2RX3 | |
| SCHEMBL546516 | 0.73 | BRAF (0.62) | BRAFRAF1KDR | |
| SCHEMBL5422515 | 0.73 | BRAF (0.60) | BRAFRAF1KDR | |
| SCHEMBL545333 | 0.73 | BRAF (0.54) | BRAFRAF1KDRMAPK14 | |
| SCHEMBL10268161 | 0.73 | BRAF (0.42) | BRAFRAF1KDRMAPK14P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |