Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17915965 | 0.88 | JAK3 (0.50) | JAK3EGFRBTKBRD4JAK1 | |
| SCHEMBL270237 | 0.85 | BRD4 (0.50) | JAK3EGFRBTKAKR1C3BRD4 | |
| SCHEMBL12111057 | 0.85 | JAK3 (0.48) | JAK3EGFRBTKBRD4ALDH1A1 | |
| SCHEMBL265824 | 0.82 | BRD4 (0.46) | JAK3BRD4JAK1JAK2RET | |
| SCHEMBL270088 | 0.81 | BRD4 (0.71) | JAK3BRD4JAK1JAK2RET | |
| Hydrochloric Acid SCHEMBL277741 | 0.80 | BRD4 (0.70) | JAK3BRD4JAK1JAK2RET | |
| SCHEMBL10260824 | 0.79 | BRD4 (0.57) | JAK3EGFRBTKBRD4ALDH1A1 | |
| SCHEMBL24124309 | 0.76 | JAK3 (0.57) | JAK3EGFRBTKBRD4ALDH1A1 | |
| SCHEMBL309668 | 0.75 | TNNI3K (0.61) | EGFRBRAFTNNI3K | |
| SCHEMBL17916028 | 0.73 | JAK3 (0.51) | JAK3EGFRBTKBRD4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133900-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-13 | — | — | US | disclosed |