Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 20/20 | 0.61 |
| ▸ | BRAF | P15056 | 8/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301265 | 0.87 | JAK1 (0.60) | TNNI3KBRAFEGFR | |
| SCHEMBL29557228 | 0.87 | TNNI3K (0.60) | TNNI3KBRAFEGFR | |
| SCHEMBL12279008 | 0.85 | TNNI3K (0.57) | TNNI3KBRAFEGFR | |
| SCHEMBL10260824 | 0.83 | BRD4 (0.57) | TNNI3KBRAFEGFR | |
| SCHEMBL302168 | 0.82 | JAK3 (0.46) | TNNI3KEGFR | |
| SCHEMBL12320534 | 0.81 | TNNI3K (0.53) | TNNI3KEGFR | |
| SCHEMBL10260435 | 0.81 | GAK (0.55) | TNNI3KBRAFEGFR | |
| SCHEMBL270501 | 0.81 | JAK1 (0.56) | TNNI3KBRAFEGFR | |
| SCHEMBL17915944 | 0.76 | JAK3 (0.67) | EGFR | |
| SCHEMBL12111287 | 0.76 | EGFR (0.50) | BRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133900-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-13 | — | — | US | disclosed |