Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.62 |
| ▸ | ACACA | Q13085 | 1/20 | 0.62 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196497 | 0.93 | ACACB (0.69) | ACACBACACAACLYPPARATSHR | |
| SCHEMBL2736899 | 0.87 | ACACB (0.74) | ACACBACACAACLYPPARATSHR | |
| SCHEMBL2737115 | 0.85 | ACACB (0.78) | ACACBACACAACLYPPARATSHR | |
| SCHEMBL27655160 | 0.85 | ACACB (0.60) | ACACBACACAACLYFFAR4FFAR1 | |
| SCHEMBL7048284 | 0.83 | ACACB (0.57) | ACACBACACAACLYPPARATSHR | |
| SCHEMBL12094483 | 0.82 | ACACB (0.88) | ACACBACACAACLYPPARATSHR | |
| SCHEMBL3748635 | 0.82 | ACACB (0.88) | ACACBACACAACLYPPARATSHR | |
| SCHEMBL8896856 | 0.81 | RIPK1 (0.44) | ACACBACACARIPK1TSHRALDH1A1 | |
| SCHEMBL25936778 | 0.80 | ACACB (0.89) | ACACBACACAACLYFFAR4FFAR1 | |
| SCHEMBL3751463 | 0.80 | ACACB (0.84) | ACACBACACAACLYPPARATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404890-A1 | Hydroxyl compounds and compositions for cholesterol management and related uses | Esperion Therapeutics Inc. (US) | 2012-01-11 | — | — | EP | disclosed |