Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15355691 | 0.91 | RIPK1 (0.37) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL15355692 | 0.88 | RIPK1 (0.39) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL19176126 | 0.87 | ACACB (0.45) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL6180287 | 0.87 | ACACB (0.45) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL12092767 | 0.86 | ACACB (0.38) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL19678191 | 0.86 | ACACB (0.44) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL19682100 | 0.86 | ACACB (0.44) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL13106139 | 0.86 | ACACB (0.44) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL13106114 | 0.85 | RIPK1 (0.42) | ACACBACACARIPK1CYP2C19HIF1A | |
| SCHEMBL6196644 | 0.85 | ACACB (0.41) | ACACBACACARIPK1CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404890-A1 | Hydroxyl compounds and compositions for cholesterol management and related uses | Esperion Therapeutics Inc. (US) | 2012-01-11 | — | — | EP | disclosed |