Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16101207 | 0.83 | CYP3A4 (0.41) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL18269858 | 0.83 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL16101584 | 0.80 | KLK5 (0.43) | — | |
| SCHEMBL18269861 | 0.77 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL17311327 | 0.75 | PDE4B (0.39) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL1135194 | 0.71 | CA1 (0.64) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL5583429 | 0.68 | PDE4B (0.82) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL500087 | 0.68 | PDE4B (0.82) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL2532328 | 0.67 | PDE4B (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5583340 | 0.67 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170066787-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. | 2017-03-09 | — | — | US | disclosed |
| US-9572823-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-9566290-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| US-9566289-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2017-02-14 | — | — | US | disclosed |
| US-20130210770-A1 | PHARMACEUTICAL FORMULATIONS | ANACOR PHARMACEUTICALS, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130064783-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-03-14 | — | — | US | disclosed |
| US-20130059803-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130059802-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20120289686-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-8115026-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20100267981-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2010-10-21 | — | — | US | disclosed |
| US-7767657-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| US-20070155699-A1 | Boron-containing small molecules | ANACOR PHARMACEUTICALS (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059802-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4A 4397/4885PDE4B 4444/4885PDE4C 4585/4885 |
| US-20170066787-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4A 4397/4885PDE4B 4444/4885PDE4C 4585/4885 |
| US-20130210770-A1 | PHARMACEUTICAL FORMULATIONS | DPM1, POLR1C, ETF1 | PDE4A 2779/4885PDE4B 3014/4885PDE4C 2762/4885 |
| US-20120289686-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4A 4397/4885PDE4B 4444/4885PDE4C 4585/4885 |
| US-20130059803-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4A 4397/4885PDE4B 4444/4885PDE4C 4585/4885 |
| US-20070155699-A1 | Boron-containing small molecules | ETF1, POLR1C, DPM1 | PDE4A 4397/4885PDE4B 4444/4885PDE4C 4585/4885 |
| US-20100267981-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4A 4397/4885PDE4B 4444/4885PDE4C 4585/4885 |
| US-20130064783-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4A 4397/4885PDE4B 4444/4885PDE4C 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.