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POLR1C

DNA-directed RNA polymerases I and III subunit RPAC1 · O15160 · POLR1C on Sugi Atlas →

1,893 patent compounds predicted against POLR1C, 1,676 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Molibresib Molibresib (SCHEMBL1872390) 1.00 1/20
Molibresib Molibresib (SCHEMBL12671490) 1.00 1/20
Molibresib Molibresib (SCHEMBL12966358) 1.00 1/20
SCHEMBL9998851 SCHEMBL9998851 0.91 1/20
SCHEMBL14756282 SCHEMBL14756282 0.88 1/20
SCHEMBL15980874 SCHEMBL15980874 0.88 1/20
SCHEMBL12966165 SCHEMBL12966165 0.87 1/20
SCHEMBL14756215 SCHEMBL14756215 0.87 1/20
SCHEMBL14756339 SCHEMBL14756339 0.87 1/20
SCHEMBL15980861 SCHEMBL15980861 0.87 1/20
SCHEMBL9998825 SCHEMBL9998825 0.86 1/20
SCHEMBL15980893 SCHEMBL15980893 0.86 1/20
SCHEMBL15980803 SCHEMBL15980803 0.86 1/20
SCHEMBL1874116 SCHEMBL1874116 0.85 1/20
SCHEMBL12671221 SCHEMBL12671221 0.85 1/20
SCHEMBL14756021 SCHEMBL14756021 0.85 1/20
SCHEMBL14756240 SCHEMBL14756240 0.85 1/20
SCHEMBL14756287 SCHEMBL14756287 0.85 1/20
SCHEMBL14756335 SCHEMBL14756335 0.85 1/20
SCHEMBL14756409 SCHEMBL14756409 0.85 1/20

Clinical trials — most relevant to POLR1C by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice PHASE4COMPLETED
Impact of Raltegravir Intensification on HIV-1-infected Subjects With Complete Viral Suppression Under Monotherapy With Protease Inhibitors PHASE3COMPLETED
Danazol for Treatment of Cytopenias in Patients With Cirrhosis PHASE2RECRUITING
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
IL-17 Role in Variants of Psoriasis nanCOMPLETED
Chronic Cough and CANVAS (Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome) nanCOMPLETED
Cohort of Tumors With POLE/D1 Mutation nanRECRUITING
miRNAs in Critical Limb Ischemia (miRNACLI) nanRECRUITING
Clinical and Dermoscopic Comparison of Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriasis Patients' Nails nanCOMPLETED
RBG: Regular, Bare, Gel: Does Type of Nail Polish Affect Bacterial Counts After Surgical Scrubbing? nanCOMPLETED
HBV-host cfDNA as Minimal Residual Tumor Marker for HBV-related HCC nanUNKNOWN
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing nanNOT_YET_RECRUITING
Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon nanCOMPLETED
Screening for Chromosomal Microarrangements by CGH-array in Developmental Anomalies of the Skin Suggestive of Mosaicism. nanCOMPLETED
An Indicator of Successful Peripheral Nerve Block nanCOMPLETED
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors nanCOMPLETED
Defining Treatment Outcomes and Genetic Architecture in Idiopathic Toe Walking* nanCOMPLETED
Establishment of Genetic Basis for Neurological Disease by Genetic Screening nanENROLLING_BY_INVITATION
Genetic Variants in Linear Localized Scleroderma nanCOMPLETED
Low-dose UVA1 Radiation in Cutaneous Lupus Patients nanCOMPLETED
Longitudinal Biomarkers With Selected Outcome Measures In CMT nanRECRUITING
Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation nanRECRUITING
The Role of Genetic Polymorphisms in Innate Immune Response Genes in Susceptibility to Infections nanCOMPLETED
Role of Metabolic Enzymes in Non-Melanoma Skin Cancer nanCOMPLETED
Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life nanRECRUITING
Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing. nanACTIVE_NOT_RECRUITING
Genetic Study of Families Affected by Paget's Disease of Bone nanCOMPLETED
Genetic Analysis of Fraser Syndrome and Fryns Syndrome nanCOMPLETED
Genetics of Atherosclerosis in Mexican Americans nanCOMPLETED
Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental Disorders nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a POLR1C binder may also engage these)

ProteinNameSimilarity
Q32L22 — 1.000 Q32L22 →
P52432 — 1.000 P52432 →
Q5R6E0 — 0.966 Q5R6E0 →
A4FUD3 — 0.964 A4FUD3 →
Q5F3X4 — 0.963 Q5F3X4 →
O08810 — 0.960 O08810 →
Q5ZJH9 — 0.959 Q5ZJH9 →
EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0.958 landscape →
PC Pyruvate carboxylase, mitochondrial 0.957 landscape →
P09605 — 0.956 P09605 →
Q93ZR1 — 0.956 Q93ZR1 →
A8FYR3 — 0.955 A8FYR3 →
O14007 — 0.955 O14007 →
Q6G543 — 0.955 Q6G543 →
F1Q749 — 0.954 F1Q749 →
O43102 — 0.954 O43102 →
B7VJG2 — 0.954 B7VJG2 →
Q3YU19 — 0.953 Q3YU19 →
Q2S9X0 — 0.953 Q2S9X0 →
P52873 — 0.953 P52873 →
P40615 — 0.953 P40615 →
Q83P06 — 0.953 Q83P06 →
Q21HQ0 — 0.953 Q21HQ0 →
A3QGT8 — 0.953 A3QGT8 →
Q9XET4 — 0.953 Q9XET4 →
P32481 — 0.953 P32481 →
Q1QDP8 — 0.953 Q1QDP8 →
Q6P8J7 — 0.953 Q6P8J7 →
Q949H0 — 0.952 Q949H0 →
P28227 — 0.952 P28227 →