Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.46 |
| ▸ | BCL6 | P41182 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10268674 | 0.89 | MAPKAPK2 (0.63) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL10269749 | 0.86 | MAPKAPK2 (0.65) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL10269701 | 0.85 | MAPKAPK2 (0.64) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL10268605 | 0.82 | MAPKAPK2 (0.74) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL10269170 | 0.81 | MAPKAPK2 (0.59) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL10268662 | 0.81 | MAPKAPK2 (0.73) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL10213601 | 0.81 | MAPKAPK2 (0.73) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL10269120 | 0.81 | MAPKAPK2 (1.00) | MAPKAPK2ROCK1BCL6CDC7HTR3E | |
| SCHEMBL758246 | 0.81 | MAPKAPK2 (0.59) | MAPKAPK2ROCK1BCL6HTR3EHTR3B | |
| SCHEMBL12393729 | 0.81 | MAPKAPK2 (0.61) | MAPKAPK2ROCK1BCL6CDC7HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885ROCK1 2438/4885BCL6 2802/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885ROCK1 2438/4885BCL6 2802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.