Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22509724 | 1.00 | HSD17B10 (0.57) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL7750667 | 0.91 | HSD17B10 (0.66) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL25801598 | 0.90 | HSD17B10 (0.48) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL10270570 | 0.84 | ROCK2 (0.45) | HSD17B10MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL23119218 | 0.84 | HSD17B10 (0.59) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL12197922 | 0.84 | HSD17B10 (0.59) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL15199100 | 0.84 | HSD17B10 (0.59) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL6385930 | 0.84 | HSD17B10 (0.62) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL12384303 | 0.84 | HSD17B10 (0.62) | HSD17B10MEN1KMT2AEPHX2GAA | |
| SCHEMBL10270129 | 0.82 | ROCK2 (0.46) | HSD17B10KMT2AEPHX2ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |