Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 10/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12680488 | 0.89 | CNR1 (0.39) | SIGMAR1CRHR1DPP4DPP8DPP9 | |
| SCHEMBL12680458 | 0.87 | ALPL (0.41) | SIGMAR1CRHR1DPP4DPP8DPP9 | |
| SCHEMBL3611015 | 0.78 | CYP2A13 (0.47) | SIGMAR1CRHR1DPP4DPP8DPP9 | |
| SCHEMBL3607437 | 0.77 | CYP2A13 (0.45) | SIGMAR1CRHR1DPP4 | |
| SCHEMBL10270029 | 0.76 | GSK3B (0.36) | SIGMAR1DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL10269950 | 0.76 | HRH4 (0.37) | SIGMAR1DPP4DPP8DPP9CNR1 | |
| SCHEMBL10270288 | 0.75 | DPP4 (0.39) | CRHR1DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL12680882 | 0.74 | GSK3B (0.48) | DPP4DPP8CNR1CNR2 | |
| SCHEMBL12680879 | 0.73 | CNR1 (0.35) | SIGMAR1DPP4DPP8DPP9CNR1 | |
| SCHEMBL12680493 | 0.69 | CYP1A2 (0.41) | SIGMAR1CRHR1DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137188-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Pharma AG (DE) | 2012-06-06 | — | — | EP | disclosed |
| WO-2008113469-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-25 | — | — | WO | disclosed |