ALPL — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL171413	0.58	11/20
SCHEMBL148344	0.68	10/20
SCHEMBL68056	0.54	10/20
SCHEMBL160276	0.42	10/20
SCHEMBL95201	0.62	9/20
Coumaphos (SCHEMBL120173)	0.60	9/20
Haloxon (SCHEMBL167194)	0.57	9/20
Adrenalone (SCHEMBL123124)	0.55	8/20
SCHEMBL137684	0.78	7/20
SCHEMBL137689	0.67	6/20
SCHEMBL189280	0.61	6/20
SCHEMBL146921	0.60	6/20
SCHEMBL1092	0.47	5/20
SCHEMBL190103	0.61	4/20
SCHEMBL70577	0.53	4/20
SCHEMBL105705	0.51	4/20
SCHEMBL25184	0.63	3/20
SCHEMBL95715	0.63	3/20
SCHEMBL95622	0.58	3/20
SCHEMBL8639	0.54	3/20

Clinical trials — most relevant to ALPL by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effectiveness of Inactive Vitamin D Supplementation in Non-Alcoholic Fatty Liver Disease Patients	PHASE3	UNKNOWN
Bovine Intestinal Alkaline Phosphatase (bIAP) Modulating Rheumatoid Arthritis	PHASE1/PHASE2	COMPLETED
Clinical Use of Stem Cells for the Treatment of Covid-19	PHASE1/PHASE2	COMPLETED
Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis	PHASE2	COMPLETED
A Study of QY101 Ointment in Subjects With Plaque Psoriasis	PHASE2	UNKNOWN
PBF-1129 in Patients With NSCLC	PHASE1	UNKNOWN
A Phase 1 Study of ZSP1602 in Participants With Advanced Solid Tumors	PHASE1	UNKNOWN
A Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects	PHASE1	COMPLETED
Effect of Food on the Pharmacokinetics of ASTX660 in Healthy Volunteers	PHASE1	COMPLETED
Phase 1b Trial of Lenvatinib Plus Pembrolizumab in Participants With Selected Solid Tumors	PHASE1	COMPLETED
A Bioequivalence Study Comparing Organic Phosphate (Sodium Glycerophosphate Injection) to Inorganic Phosphate (Sodium Phosphates Injection, USP)	PHASE1	COMPLETED
Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in the Treatment of Advanced Solid Tumor	PHASE1	COMPLETED
Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals	nan	UNKNOWN
Characteristics and Predictors of Liver Injury in Cyclin-dependent Kinase Inhibitors 4/6 (CDK4/6)-Treated Patients With Advanced Breast Cancer	nan	COMPLETED
Serum Alkaline Phosphatase Levels In Healthy Turkish Children	nan	COMPLETED
Compare Different Response Evaluations to Neoadjuvant Chemotherapy for Gastric Cancer	nan	UNKNOWN
Resistance Training in Older Adults With Limitations in Mobility	nan	COMPLETED
Molecular Evaluation of Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer	nan	COMPLETED
Safety Study of Black Cohosh Use by Postmenopausal Women on the Liver	nan	COMPLETED
Registry of Patients With Hypophosphatasia	nan	ENROLLING_BY_INVITATION
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)	nan	RECRUITING
Checkpoint Inhibitor-induced Liver Injury	nan	RECRUITING
A Cross-sectional Study on IBS Subtypes, Chinese Medicine Pattern and Host-gut Microbiota Metabolic Interactions	nan	COMPLETED
Therapeutic Role of Flax Seed for Poly Cystic Ovary Syndrome	nan	COMPLETED
The Changes of Body Composition, Glucolipid Metabolism and Bone Metabolism in Obese Children After Weight Loss	nan	COMPLETED
Acute Hepatitis in Pediatrics	nan	RECRUITING
DHB Supplement Interaction Study	nan	WITHDRAWN
Inhaled Fluticasone Propionate: Effect on Parameters of Bone Metabolism in Patients With Mild to Moderate Asthma	nan	WITHDRAWN
Bariatric-metabolic Surgery - the Effect of Postoperative Exercising on Sarcopenia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ALPL binder may also engage these)

Protein	Name	Similarity
P09242	—	1.000	P09242 →
P08289	—	1.000	P08289 →
Q29486	—	0.998	Q29486 →
P09487	—	0.997	P09487 →
Q92058	—	0.991	Q92058 →
ALPI	Intestinal-type alkaline phosphatase	0.986	landscape →
P24823	—	0.985	P24823 →
P15693	—	0.984	P15693 →
ALPG	Alkaline phosphatase, germ cell type	0.983	landscape →
P19111	—	0.981	P19111 →
ALPP	Alkaline phosphatase, placental type	0.978	landscape →
P24822	—	0.978	P24822 →
P83456	—	0.976	P83456 →
Q3TIW9	—	0.961	Q3TIW9 →
P51740	—	0.957	P51740 →
Q6UWV6	—	0.955	Q6UWV6 →
Q5EZ72	—	0.954	Q5EZ72 →
O77564	—	0.947	O77564 →
Q05927	—	0.947	Q05927 →
NT5E	5'-nucleotidase	0.946	landscape →
Q9CZR2	—	0.945	Q9CZR2 →
P21588	—	0.944	P21588 →
FOLH1	Glutamate carboxypeptidase 2	0.943	landscape →
O35409	—	0.943	O35409 →
F8S0Z7	—	0.942	F8S0Z7 →
NAALAD2	N-acetylated-alpha-linked acidic dipeptidase 2	0.940	landscape →
B6EWW8	—	0.939	B6EWW8 →
Q61503	—	0.939	Q61503 →
Q5RDN7	—	0.938	Q5RDN7 →
P70627	—	0.937	P70627 →