Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272091 | 0.91 | SYK (0.53) | SYKCHEK2LRRK2 | |
| SCHEMBL10272204 | 0.91 | SYK (0.66) | SYKLRRK2 | |
| SCHEMBL2719001 | 0.89 | SYK (0.50) | SYK | |
| SCHEMBL10271909 | 0.87 | SYK (0.49) | SYKCHEK2LRRK2 | |
| SCHEMBL2728953 | 0.85 | SYK (0.53) | SYK | |
| SCHEMBL2728948 | 0.85 | SYK (0.53) | SYK | |
| SCHEMBL2729996 | 0.84 | SYK (0.58) | SYKLRRK2 | |
| SCHEMBL10271847 | 0.84 | SYK (0.58) | SYKLRRK2 | |
| SCHEMBL2719516 | 0.83 | SYK (0.50) | SYK | |
| SCHEMBL10272207 | 0.82 | SYK (0.55) | SYKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |