Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271725 | 0.90 | SYK (0.51) | SYKLRRK2 | |
| SCHEMBL2718144 | 0.88 | SYK (0.38) | SYK | |
| SCHEMBL10271836 | 0.87 | SYK (0.64) | SYKLRRK2CHEK2 | |
| SCHEMBL10272091 | 0.86 | SYK (0.53) | SYKLRRK2CHEK2PDE2ATP53 | |
| SCHEMBL2730389 | 0.80 | SYK (0.53) | SYK | |
| SCHEMBL2730393 | 0.80 | SYK (0.53) | SYK | |
| SCHEMBL10272204 | 0.78 | SYK (0.66) | SYKLRRK2 | |
| SCHEMBL2716075 | 0.77 | SYK (0.46) | SYKMAPT | |
| SCHEMBL2716073 | 0.77 | SYK (0.46) | SYKMAPT | |
| SCHEMBL10272207 | 0.77 | SYK (0.55) | SYKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |