Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719190 | 0.89 | SYK (0.52) | SYKAURKATNIKBTKLRRK2 | |
| SCHEMBL10272206 | 0.88 | SYK (0.48) | SYKAURKATNIKBTKLRRK2 | |
| SCHEMBL10272079 | 0.86 | SYK (0.70) | SYKAURKATNIKBTKNPC1 | |
| SCHEMBL2716327 | 0.84 | SYK (0.49) | SYKAURKATNIKBTKLRRK2 | |
| SCHEMBL2717505 | 0.83 | SYK (0.50) | SYKAURKATNIKBTKLRRK2 | |
| SCHEMBL16743188 | 0.82 | SYK (0.60) | SYKTNIKBTKNPC1 | |
| SCHEMBL16194907 | 0.82 | SYK (0.75) | SYK | |
| SCHEMBL14977146 | 0.82 | SYK (0.75) | SYK | |
| SCHEMBL10271839 | 0.81 | SYK (0.49) | SYKAURKATNIKNPC1 | |
| SCHEMBL10271722 | 0.80 | SYK (0.56) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |