Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.70 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272080 | 0.88 | SYK (0.64) | SYKAURKATNIKBTKNPC1 | |
| SCHEMBL2719190 | 0.86 | SYK (0.52) | SYKAURKATNIKBTKNPC1 | |
| SCHEMBL10271838 | 0.86 | SYK (0.52) | SYKAURKATNIKBTKNPC1 | |
| SCHEMBL2717505 | 0.84 | SYK (0.50) | SYKAURKATNIKBTKNPC1 | |
| SCHEMBL2716327 | 0.83 | SYK (0.49) | SYKAURKATNIKBTKNPC1 | |
| SCHEMBL1354375 | 0.83 | SYK (1.00) | SYK | |
| SCHEMBL1354369 | 0.83 | SYK (1.00) | SYK | |
| SCHEMBL16743177 | 0.83 | SYK (0.74) | SYKAURKATNIKBTK | |
| SCHEMBL10272087 | 0.82 | SYK (0.47) | SYKAURKA | |
| SCHEMBL10272161 | 0.81 | SYK (0.64) | SYKAURKATNIKBTKNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |