Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 14/20 | 0.59 |
| ▸ | TNF | P01375 | 1/20 | 0.59 |
| ▸ | IL1B | P01584 | 1/20 | 0.59 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18900417 | 0.88 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26320556 | 0.88 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282837 | 0.88 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL31316579 | 0.88 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26320535 | 0.87 | CRBN (0.62) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26320573 | 0.87 | CRBN (0.62) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26324033 | 0.87 | CRBN (0.62) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282858 | 0.87 | CRBN (0.62) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26320519 | 0.87 | CRBN (0.62) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL19526118 | 0.86 | CRBN (0.67) | CRBNDDB1TNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066656-B1 | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AS ANTITUMOR AGENTS | CELGENE CORP (US) | 2012-04-25 | — | — | EP | disclosed |