Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.67 |
| ▸ | DDB1 | Q16531 | 19/20 | 0.67 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.67 |
| ▸ | TNF | P01375 | 1/20 | 0.67 |
| ▸ | IL1B | P01584 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283120 | 0.91 | CRBN (0.68) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL23355751 | 0.90 | CRBN (0.69) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL18946147 | 0.88 | DDB1 (0.67) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL18509378 | 0.87 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL328520 | 0.87 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21844459 | 0.87 | DDB1 (0.77) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL17552858 | 0.87 | DDB1 (0.73) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL10271852 | 0.86 | CRBN (0.59) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL282837 | 0.86 | CRBN (0.63) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31316579 | 0.86 | CRBN (0.63) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239144-A1 | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AS ANTI-CANCER AGENTS | Celgene Corporation (US) | 2017-11-01 | — | — | EP | disclosed |